ea0077p172 | Metabolism, Obesity and Diabetes | SFEBES2021
Villalobos Elisa
, Chua EE June
, Miguelez-Crespo Allende
, Morgan Ruth
, Andrew Ruth
, Nixon Mark
, Walker Brian
Background: Glucocorticoids (GCs) modulate glucose homeostasis by acting on metabolic tissues including liver, adipose, and skeletal muscle. ABCC1 is a transmembrane drug-resistance transporter expressed in adipose tissue and skeletal muscle with previously unknown physiological function. We recently showed that ABCC1 modulates intracellular GC concentrations and action in adipose. Here, we tested the hypothesis that Abcc1 regulates GC concentrations in skeletal mu...